Mixed metal metal-organic framework synergized with functional liposomes boosts bipolar-driven organic...

Organic photoelectrochemical transistor (OPECT) has emerged as a promising platform for investigating photoactive biomolecular interactions and advancing bioanalytical detection systems. However, many important challenges and hurdles remain implementing high gating effects and sensitive biosensing detection caused by the inherent limitations of the configuration of the photoelectrode structures and innovative biosensing. Inspired by the self-powered photoelectrochemical (PEC) systems and liposomes-assisted bioanalysis for signal amplification, a bipolar-driven poly(3,4-ethylenedioxythiophene): poly(styrene sulfonate) (PEDOT:PSS) OPECT based on CdS/Mixed Metal Metal-Organic Framework (MM-MOF) photoanode and a poly(1,4-diethynylbenzene) (pDEB) cathode is proposed, and exhibits a considerable current gain of ca. 2876, which is significantly superior to conventional single-photoelectrode structures. Besides, the bipolar OPECT platform is cooperated with the target-mediated etching reactions by a sandwich immune-sensing interface of glucose oxidase (GOx)-loaded liposomes, for bioanalytical detection realizing ultra-sensitive prostate-specific antigen (PSA) detection with an expansive linear range from 10 fg mL^-1 to 10 ng mL^-1 with a low detection limit of 7 fg mL^-1.