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The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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TMED10 expression in human cutaneous malignant melanoma.

Tiziana Annese¹, Daniela Coltrini², Mirella Belleri²

¹Department of Medicine and Surgery, LUM University, Casamassima, Bari, Italy.

Pathology, Research and Practice

|August 30, 2025

Summary

TMED10 protein is upregulated in cutaneous malignant melanoma (cMM), correlating with advanced tumor characteristics and poorer survival. This suggests TMED10 may promote melanoma progression and could be a therapeutic target.

Keywords:

Immunohistochemistry Melanoma Morphometry TMED10

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Area of Science:

Oncology
Molecular Biology
Cell Biology

Background:

TMED10 is implicated in protein secretion and trafficking.
Its role in human cutaneous melanoma (cMM) remains unexplored.
TMED10 may have dual roles in tumorigenesis.

Purpose of the Study:

To investigate TMED10 expression in benign and malignant human melanocytic tumors.
To determine the correlation of TMED10 with melanoma progression and clinical features.

Main Methods:

In silico analysis of TMED10 gene expression in normal skin versus cMM.
Immunohistochemistry and digital morphometry of TMED10 protein in 60 human samples.
Analysis of TMED10 expression relative to Clark level, Breslow T category, BRAF mutation, and patient survival.

Main Results:

TMED10 is upregulated in cMM compared to normal skin.
Higher TMED10 expression correlates with increased Clark level, BRAF^V600E mutation, and reduced patient survival.
TMED10 protein levels increase with Breslow T category in tumor cells and neovasculature.

Conclusions:

TMED10 exhibits a pro-tumorigenic function in human cMM.
TMED10 may contribute to melanoma progression, neovascularization, and immune evasion.
TMED10 represents a potential therapeutic target for cMM.