Role of mesencephalic glycine in locomotor activity

Microinjection of glycine (20 micrograms) into the ventral mesencephalon of rats caused a stimulation of locomotor activity. Microinjection of haloperidol (5 micrograms) into the nucleus accumbens immediately before the glycine injection did not reduce this locomotor stimulation. In rats with 6-hydroxydopamine-induced destruction of mesolimbic dopamine (DA) terminals the ability of apomorphine (0.1 mg/kg, s.c.) to stimulate locomotor activity was reduced by microinjection of the glycine antagonist strychnine into the ventral mesencephalon. Increased glycinergic activity in the ventral mesencephalon therefore appears to stimulate locomotor activity by a mechanism other than the activation of mesolimbic DA neurons.