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Biomechanics in miniature: microfluidic-based in vitro modeling to decipher mechanobiological phenomena
Hye Jin Hong1, Na-Hyun Lee1, Hye Sung Kim2
1Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of Korea; Mechanobiology Dental Medicine Research Center, Dankook University, Cheonan 31116, Republic of Korea.
None:
Mechanobiology is a rapidly advancing field, offering innovative insights and therapeutic strategies for a range of pathophysiological conditions. Central to this progress is the ability to replicate complex cellular and tissue microenvironments in vitro. Microfluidic systems, with their precision-engineered designs, dynamic fluid control, and spatial manipulation, serve as versatile platforms for this purpose. By effectively integrating modeling and sensing capabilities, these systems further provide valuable insights into complex cellular mechanosensing events. In this review, we highlight the latest advances in microfluidic technologies, their significance in replicating living microenvironments, and the challenges they present, with a particular focus on their contributions to unraveling mechanobiological mechanisms and exploring potential therapeutic strategies.
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