APOE ε4-related differences in brain structure, function, and connectivity at midlife: A scoping review
Rikki Lissaman1, Sidra Anjum2, Andrea Quaiattini3
1Department of Psychiatry, McGill University, Montreal, QC, Canada; Department of Psychology, Royal Holloway, University of London, Egham, Surrey, UK.
The Journal of Prevention of Alzheimer'S Disease
|August 30, 2025
Summary
The apolipoprotein E (APOE) ε4 allele, a risk factor for Alzheimer's disease, shows little impact on brain structure in middle-aged adults. Further research is needed to understand its effects on brain function and connectivity.
Area of Science:
- Neuroscience
- Genetics
- Radiology
Background:
- The apolipoprotein E (APOE) ε4 allele is a significant genetic risk factor for late-onset Alzheimer's disease (AD).
- The precise mechanisms and timing of APOE ε4's influence on the brain remain unclear.
- Understanding these effects is crucial for early intervention strategies.
Conclusions:
- The apolipoprotein E (APOE) ε4 allele appears to have minimal influence on brain structure during midlife.
- Further research is necessary to fully characterize the impact of APOE ε4 on brain function and connectivity in middle age.
- Addressing limitations in sample diversity and size is essential for future studies.
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