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Action Potentials01:41

Action Potentials

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Non-invasive action potential recordings using printed electrolyte-gated polymer field-effect transistors.

Adrica Kyndiah1, Giulia Zoe Zemignani2,3, Carlotta Ronchi2

  • 1Center for Nano Science and Technology, Istituto Italiano di Tecnologia, Milano, Italy. adrica.kyndiah@iit.it.

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|August 30, 2025
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Summary

Researchers developed a new non-invasive method to record action potentials (APs) from heart cells. This high-throughput platform uses inkjet-printed electronics for faster disease diagnosis and drug discovery.

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Area of Science:

  • Biomedical Engineering
  • Cardiology
  • Materials Science

Background:

  • Action potentials (APs) are crucial for excitable cell function.
  • Current AP recording methods like patch clamp are invasive and low-throughput.
  • Existing non-invasive techniques lack accuracy for disease and drug studies.

Purpose of the Study:

  • To develop a scalable, high-throughput, and non-invasive platform for recording cellular action potentials.
  • To enable accurate measurements of disease states and drug effects on excitable cells.
  • To improve the efficiency of disease diagnosis and drug discovery.

Main Methods:

  • Utilized an inkjet-printed polymer semiconductor in an Electrolyte-Gated Field-Effect Transistor (EGFET) configuration.
  • Developed a novel non-invasive method for recording APs from human stem cell-derived cardiomyocytes.
  • Demonstrated high sensitivity through detection of drug-induced membrane potential oscillations.

Main Results:

  • Achieved reliable, non-invasive recording of APs with patch clamp-like quality.
  • Successfully detected drug-induced pro-arrhythmic membrane potential oscillations (early/delayed afterdepolarizations).
  • Showcased the potential for significantly higher throughput compared to traditional methods.

Conclusions:

  • The developed EGFET platform offers a promising non-invasive alternative for AP recording.
  • This technology can accelerate disease modeling, drug screening, and safety pharmacology.
  • Enhances the study of abiotic/biotic interfaces with excitable cells.