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Updated: Sep 9, 2025
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Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience
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Deciphering transcriptomic changes in chemobrain: a comprehensive review
Tusar Kanta Acharya1, Yuan Pan1,2,3, Peter M Grace1,3
1Laboratories of Neuroimmunology, Department of Symptom Research, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Acta Neuropathologica Communications
|August 30, 2025
Summary
Chemotherapy-induced cognitive impairments (CICI) affect cancer survivors
Area of Science:
- Neuroscience
- Oncology
- Genomics
Background:
- Chemotherapy-induced cognitive impairments (CICI), or "chemobrain," are a significant side effect for cancer survivors.
- These impairments affect memory, multitasking, and overall quality of life.
Purpose of the Study:
- To review the molecular mechanisms of CICI, focusing on transcriptomic data.
- To understand the link between chemotherapy agents and cognitive dysfunction.
Main Methods:
- RNA sequencing
- cDNA microarrays
- Single-cell transcriptomics
- Spatial transcriptomics
Main Results:
- Transcriptomic analyses reveal altered gene expression profiles in CICI.
- Key implicated mechanisms include blood-brain barrier disruption, neuroinflammation, and oxidative stress.
- Specific chemotherapy agents like doxorubicin, cisplatin, and paclitaxel are associated with CICI.
Conclusions:
- Transcriptomics offers crucial insights into CICI pathophysiology.
- Developing single-cell atlases and spatial transcriptomics can reveal cellular heterogeneity and gene expression dynamics.
- Integrating transcriptomic findings with clinical data is vital for personalized interventions to improve survivors' cognitive health.
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