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Updated: Sep 9, 2025
08:25
Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
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Guidelines for the Naming of Circular RNAs
Pengjie Tao1, Wenqin Zhou2, Tianzhao Xu3
1School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Advances in Experimental Medicine and Biology
|August 31, 2025
Summary
A standardized naming system for circular RNAs (circRNAs) is crucial for clear scientific communication. This proposal offers a systematic approach to naming circRNAs, improving research reproducibility and understanding.
Area of Science:
- Molecular Biology
- Genomics
- Bioinformatics
Background:
- Circular RNAs (circRNAs) are key posttranscriptional regulators with unique stability and functions.
- Current circRNA research faces challenges due to the lack of a standardized nomenclature system.
- Ambiguous naming hinders effective scientific communication and data interpretation.
Purpose of the Study:
- To address the need for a unified naming system for circular RNAs (circRNAs).
- To review the historical development and current state of circRNA nomenclature.
- To propose a systematic approach for naming circRNAs to improve clarity and reproducibility.
Main Methods:
- Historical analysis of circRNA nomenclature development.
- Review of existing databases and their role in shaping nomenclature.
- Proposal of a systematic naming convention incorporating transcript references and structural annotations.
Main Results:
- Identified significant ambiguity in current circRNA naming conventions.
- Highlighted the impact of multiple circRNAs originating from single gene loci.
- Proposed a structured nomenclature system using 'circ' prefix, GENCODE/Ensembl references, and feature annotations.
Conclusions:
- A standardized circRNA nomenclature is essential for advancing the field.
- The proposed system enhances clarity, facilitates data sharing, and ensures reproducibility.
- Adoption of this nomenclature will accelerate circRNA research and understanding.
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