Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

34
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
34
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

24
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
24

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantifying and Comparing Training Load Metrics in Cycling: A Methodology Review.

International journal of sport nutrition and exercise metabolism·2026
Same author

Multidimensional Determinants of Food and Nutritional Insecurity Among Older Adults: A Scoping Review.

Healthcare (Basel, Switzerland)·2026
Same author

Correction to "Therapeutic Role of Deep Eutectic Solvents Based on Menthol and Saturated Fatty Acids on Wound Healing".

ACS applied bio materials·2026
Same author

International Union of Angiology (IUA) Consensus Document on Enhanced Recovery after Surgery (ERAS) in Vascular Surgery.

International angiology : a journal of the International Union of Angiology·2026
Same author

Torsed Riedel's lobe.

Pediatric radiology·2026
Same author

Neuroinflammatory Biomarkers in Chronic Low Back Pain: Mechanisms, Clinical Evidence, and Translational Challenges.

Biomedicines·2026

Related Experiment Video

Updated: Sep 9, 2025

A Simplified Technique for Producing an Ischemic Wound Model
12:00

A Simplified Technique for Producing an Ischemic Wound Model

Published on: May 2, 2012

17.4K

Using Pedal Acceleration Time To Predict Ischemic Wound Healing In Diabetic Patients.

Eduardo Silva1, Joana Iglésias1, Pedro Lima2

  • 1Department of Angiology and Vascular Surgery, Coimbra Local Health Unit, Coimbra, Portugal.

Portuguese Journal of Cardiac Thoracic and Vascular Surgery
|August 31, 2025
PubMed
Summary
This summary is machine-generated.

Pedal acceleration time (PAT) effectively predicts wound healing in diabetic patients with peripheral arterial disease (PAD). A PAT of 180 ms or less indicates good healing potential, while higher values correlate with worse outcomes like amputation.

Keywords:
Diabetes MellitusDiabetic FootPedal Acceleration TimePeripheral Arterial DiseaseWounds

More Related Videos

Demonstration of the Rat Ischemic Skin Wound Model
08:35

Demonstration of the Rat Ischemic Skin Wound Model

Published on: April 1, 2015

21.5K
Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
07:56

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model

Published on: January 10, 2025

732

Related Experiment Videos

Last Updated: Sep 9, 2025

A Simplified Technique for Producing an Ischemic Wound Model
12:00

A Simplified Technique for Producing an Ischemic Wound Model

Published on: May 2, 2012

17.4K
Demonstration of the Rat Ischemic Skin Wound Model
08:35

Demonstration of the Rat Ischemic Skin Wound Model

Published on: April 1, 2015

21.5K
Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
07:56

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model

Published on: January 10, 2025

732

Area of Science:

  • Vascular Medicine
  • Diabetology
  • Wound Healing Research

Background:

  • Diabetes Mellitus is a primary driver of peripheral arterial disease (PAD), often leading to medial arterial calcification.
  • Ankle-brachial index (ABI) is limited in diabetic patients due to calcification.
  • Pedal acceleration time (PAT) offers a diagnostic alternative by measuring systolic acceleration in foot arteries.

Purpose of the Study:

  • To validate Pedal acceleration time (PAT) as a predictor of wound healing in diabetic patients with PAD.
  • To assess PAT's ability to predict the need for revascularization or amputation.
  • To confirm the established 180 ms PAT cut-off in this patient population.

Main Methods:

  • Retrospective cross-sectional study of diabetic patients with PAD and lower limb wounds.
  • Individual limb assessment for bilateral wounds; exclusion of limbs with unmeasurable PAT.
  • Follow-up classification of limbs into healed wounds (HW), non-healed wounds (NHW), revascularized, or amputated.
  • Receiver Operating Characteristic (ROC) curve analysis to determine PAT cut-off for wound healing.

Main Results:

  • 100 limbs from 88 patients (80.68% male, median age 75) were analyzed.
  • The validated cut-off for wound healing was 180.5 ms.
  • Outcomes included 26% HW, 31% NHW, 33% revascularized, and 7% amputations.
  • Mean PAT: 159.81 ms (HW), 199.32 ms (NHW), 239.18 ms (revascularized), 279.14 ms (amputated).
  • NHW limbs (61.3%) had PAT >180 ms vs. 19.2% of HW limbs (p<0.001, OR=6.65).

Conclusions:

  • The 180 ms PAT cut-off is validated for predicting wound healing in diabetic patients with PAD.
  • Higher PAT values are significantly associated with poorer outcomes, including revascularization and amputation.
  • In non-healed wounds, PAT values closer to 180 ms indicated a more favorable healing trajectory.