Associations between adverse childhood experiences and vascular indicators of atherosclerosis measured in childhood and early to mid-adulthood: A systematic review
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View abstract on PubMed
Summary
This summary is machine-generated.Adverse childhood experiences are linked to early signs of atherosclerosis, particularly arterial stiffness. More research is needed to confirm these findings and understand the underlying mechanisms for cardiovascular disease risk.
Area Of Science
- Cardiovascular Science
- Developmental Psychology
- Public Health
Background
- Adverse childhood experiences (ACEs) are linked to increased cardiovascular disease (CVD) risk.
- Mechanisms connecting ACEs to CVD remain poorly understood.
- Vascular function is a key indicator of subclinical atherosclerosis.
Purpose Of The Study
- To systematically review associations between ACEs and vascular indicators of subclinical atherosclerosis.
- To explore potential mediating or moderating variables in these associations.
Main Methods
- Systematic literature search conducted through May 2024.
- Included cross-sectional and longitudinal studies measuring ≥5 ACEs and ≥1 vascular indicators.
- Followed Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines.
Main Results
- 10 studies (N=4784) met inclusion criteria, all using retrospective ACEs measurement.
- Strongest evidence links ACEs to arterial stiffness (5/8 studies).
- Limited evidence suggests ACEs associate with atherosclerotic progression and impaired endothelial function.
Conclusions
- ACEs are associated with subclinical atherosclerotic progression, but evidence quantity and quality are low.
- Further prospective studies are needed to identify vascular changes and analyze mediating/moderating variables.
- Understanding these mechanisms is crucial for mitigating CVD risk associated with ACEs.
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