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Updated: Sep 9, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

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Recent progress in anti-atherosclerosis strategies and prospective therapeutic targets

Zhongmin Wang1, Xiao He1, Huayang Bai1

  • 1Chongqing Key Laboratory of Medicinal Chemistry and Molecular Pharmacology, Chongqing University of Technology, Chongqing 400054, China.

International Journal of Pharmaceutics
|August 31, 2025
PubMed

Insights

This review explores advanced atherosclerosis treatments, including small molecules, macromolecules like PCSK9 inhibitors, and nanomedicine. It highlights innovative strategies to manage this challenging cardiovascular disease.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Nanotechnology

Background:

  • Atherosclerosis involves lipid accumulation and plaque formation, leading to arterial stenosis.
  • Current treatments manage progression but do not cure, posing ongoing challenges.
  • Biomedical advancements necessitate novel therapeutic approaches for atherosclerosis.

Purpose of the Study:

  • To systematically review recent advancements in atherosclerosis treatment.
  • To cover small molecule drugs, macromolecular therapies, and nanomedicine.
  • To discuss the potential and challenges of innovative atherosclerosis therapies.

Main Methods:

  • Literature review of small molecule drugs (protein target inhibitors/agonists, natural compounds).
  • Review of macromolecular drugs, focusing on proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors.
  • Analysis of nanomedicine applications and synergistic therapeutic effects.

Main Results:

  • Small molecules utilize protein target modulation and natural compounds.
  • Macromolecular strategies include advanced PCSK9 inhibitors.
  • Nanomedicine offers synergistic effects and innovative treatment designs.

Conclusions:

  • Recent strategies show promise in managing atherosclerosis.
  • Challenges remain in translating novel therapies into clinical practice.
  • Innovative design concepts are crucial for future atherosclerosis treatment development.
Keywords:
AtherosclerosisDrugNanomedicinePCSK9iTreatment strategies

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