Related Experiment Video

Updated: Sep 9, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

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New role of obscure acylation modifications in cardiovascular diseases: what's beyond?

Zhongyi Zhang1, Wei Hu1, Qian Ding1

  • 1School of Pharmacy and Laboratory of Drug Discovery from Natural Resources and Industrialization, Macau University of Science and Technology, Macau.

Life Sciences
|August 31, 2025
PubMed

Insights

Obscure acylation modifications, like succinylation and lactylation, are vital metabolic sensors in cardiovascular health. Dysregulation of these processes contributes to heart disease, offering new therapeutic targets.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • Cardiovascular diseases are a leading cause of death globally.
  • Molecular mechanisms underlying cardiovascular diseases are not fully understood.
  • Emerging research points to obscure acylation modifications as key regulators of cardiac function.

Purpose of the Study:

  • To review the role of obscure acylation modifications in cardiovascular diseases.
  • To explore the link between metabolic sensing and cardiac pathogenesis.
  • To discuss potential therapeutic strategies and future research directions.

Main Methods:

  • Literature review of recent advances in post-translational modifications.
  • Synthesis of evidence linking acylation dysregulation to cardiovascular pathologies.
  • Discussion of therapeutic targets and predictive modeling strategies.

Main Results:

  • Obscure acylations (e.g., succinylation, lactylation) act as metabolic sensors in the heart.
  • Dysregulated acylation impacts mitochondrial function, gene expression, and cellular signaling.
  • These modifications are implicated in heart failure, ischemic injury, and atherosclerosis.

Conclusions:

  • Targeting acyl-modifying enzymes presents a potential therapeutic avenue for cardiovascular diseases.
  • Machine learning offers innovative strategies for predicting acylation modifications.
  • Further research into obscure acylation modifications could yield novel biomarkers and precision therapies.

Keywords:
AcylationCardiovascular diseasesHistone deacetylases (HDACs)Post-translational modificationsSirtuins (SIRTs)

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