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Screening for endocrine hypertension in China: protocol for a multicentre prospective cohort study
Zhanyang Zhou1, Zheng Yin1, Huanhuan Miao1
1Heart Failure Center, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China.
BMJ Open
|August 31, 2025
Summary
This study investigates endocrine hypertension in China, focusing on primary aldosteronism (PA), Cushing
Area of Science:
- Endocrinology
- Hypertension Research
- Epidemiology
Background:
- Secondary hypertension affects 5%-10% of hypertensive patients.
- Endocrine causes like primary aldosteronism (PA), Cushing's syndrome (CS), and pheochromocytoma/paraganglioma (PPGL) are common and harmful.
- Large-scale epidemiological data on endocrine hypertension in China are lacking.
Purpose of the Study:
- To investigate the epidemiological characteristics of endocrine hypertension in the Chinese hypertensive population.
- To identify the prevalence of PA, CS, and PPGL.
- To establish standardized detection methods for endocrine hypertension.
Main Methods:
- Multicenter prospective cohort study.
- Standardized clinical assessments and biochemical tests.
- Mass spectrometry-based screening for PA, CS, and PPGL.
Main Results:
- Prevalence and characteristics of endocrine hypertension will be determined.
- Standardized detection methods will be established.
- Participants will be followed for at least 1 year.
Conclusions:
- This study will provide crucial epidemiological data on endocrine hypertension in China.
- Findings will aid in early diagnosis and management of PA, CS, and PPGL.
- Standardized methods will improve diagnostic accuracy and patient outcomes.
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