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Radiation Recall Dermatitis Following Capivasertib Administration.
Yuhao Shi1, Ian W Tattersall2, Boris Kobrinsky3
1Department of Radiation Oncology, New York University Grossman School of Medicine, New York, New York.
Practical Radiation Oncology
|August 31, 2025
Summary
Radiation recall dermatitis occurred in a patient treated with capivasertib, a PI3K/Akt pathway inhibitor, for metastatic breast cancer. This rare adverse effect highlights the need for caution when using capivasertib in patients with prior radiation therapy.
Area of Science:
- Oncology
- Pharmacology
Background:
- Radiation recall dermatitis is a rare adverse effect.
- Capivasertib is a PI3K/Akt pathway inhibitor approved for breast cancer.
- Its safety with palliative radiation is unknown.
Purpose of the Study:
- To report a case of radiation recall dermatitis.
- To discuss capivasertib's safety in patients with prior radiation.
Main Methods:
- Case report of a metastatic breast cancer patient.
- Patient received capivasertib after prior radiation to the lower extremity.
Main Results:
- The patient developed radiation recall dermatitis.
- Treatment included corticosteroids, antibiotics, and switching to alpelisib.
Conclusions:
- Capivasertib may trigger radiation recall dermatitis.
- Caution is advised when using capivasertib in patients with prior radiation history.
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