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Enhancing Cannabidiol Bioavailability: Development and Evaluation of an Amorphous Cannabidiol Powder Formulation.
Hiroki Aoyama1, Tatsuya Ogawa1, Hitomi Ozawa-Umeta1
1Therabiopharma Inc.
Journal of Nutritional Science and Vitaminology
|August 31, 2025
Summary
Researchers developed an amorphous cannabidiol (CBD) powder to overcome low bioavailability. This enhanced formulation significantly increases CBD absorption, paving the way for improved use in food and supplements.
Area of Science:
- Pharmacology
- Materials Science
Background:
- Cannabidiol (CBD) possesses numerous beneficial properties, including antioxidant, anti-inflammatory, and anxiolytic effects.
- Clinical applications of CBD are hindered by its inherently low oral bioavailability.
- Developing advanced delivery systems is crucial to enhance CBD's therapeutic potential.
Purpose of the Study:
- To develop an amorphous cannabidiol (CBD) powder formulation with improved bioavailability.
- To evaluate the pharmacokinetic profile of the amorphous CBD formulation in rats.
- To assess the impact of different polymers on CBD absorption.
Main Methods:
- An amorphous CBD powder was prepared using a food-grade solvent shift method.
- Pharmacokinetic studies were conducted in Sprague-Dawley rats, comparing amorphous formulations (F3 with PVP, F4 with HPMC) to crystalline CBD isolate.
- Key pharmacokinetic parameters including Cmax, AUC0-6h, and Tmax were analyzed.
Main Results:
- Amorphous CBD formulations exhibited significantly enhanced bioavailability compared to crystalline CBD.
- The Cmax increased by 3.9-fold (F3) and 3.0-fold (F4).
- AUC0-6h values were 5.3-fold (F3) and 5.2-fold (F4) higher, with significantly reduced Tmax.
Conclusions:
- The developed amorphous CBD powder formulation demonstrates superior bioavailability.
- The use of polymers like PVP and HPMC effectively enhances CBD absorption.
- This formulation holds promise for increasing the efficacy of CBD in food and supplement applications.
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