Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

1.4K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.4K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

33
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
33
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

54
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
54
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

40
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
40
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

889
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
889
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

45
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
45

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

JCS/JACR 2021 Guideline on Rehabilitation in Patients With Cardiovascular Disease.

Circulation journal : official journal of the Japanese Circulation Society·2022
Same author

New quantitative indices of cardiac amyloidosis with <sup>99m</sup>Tc-pyrophosphate scintigraphy.

Japanese journal of radiology·2022
Same author

NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload.

Circulation·2022
Same author

Isoproterenol loading transesophageal echocardiography in atrial fibrillation.

The international journal of cardiovascular imaging·2022
Same author

Effect of ipragliflozin on carotid intima-media thickness in patients with type 2 diabetes: a multicenter, randomized, controlled trial.

European heart journal. Cardiovascular pharmacotherapy·2022
Same author

Association of Microluminal Structures Assessed by Optical Coherence Tomography With Local Inflammation in Adjacent Epicardial Adipose Tissue and Coronary Plaque Characteristics in Fresh Cadavers.

Circulation journal : official journal of the Japanese Circulation Society·2022

Related Experiment Video

Updated: Sep 9, 2025

Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
04:40

Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models

Published on: January 5, 2024

2.6K

Cancer-Associated Thrombosis, With a Focus on Ischemic Heart Disease.

Tomoya Hara1, Masataka Sata1

  • 1Department of Cardiovascular Medicine, Tokushima University Graduate School of Biomedical Sciences.

Circulation Journal : Official Journal of the Japanese Circulation Society
|August 31, 2025
PubMed
Summary

Cancer-associated thrombosis (CAT) involves arterial and venous thromboembolism. Early diagnosis and treatment are crucial as CAT significantly worsens cancer patient prognosis.

Keywords:
Arterial thromboembolism (ATE)Cancer-associated thrombosis (CAT)Ischemic heart disease (IHD)

More Related Videos

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques
06:29

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Published on: June 11, 2019

10.5K
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.0K

Related Experiment Videos

Last Updated: Sep 9, 2025

Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
04:40

Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models

Published on: January 5, 2024

2.6K
Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques
06:29

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Published on: June 11, 2019

10.5K
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.0K

Area of Science:

  • Oncology
  • Hematology
  • Thrombosis Research

Background:

  • Cancer is a primary risk factor for thrombosis.
  • Cancer-associated thrombosis (CAT) includes both arterial and venous thromboembolism.
  • CAT presents a significant risk for poor prognosis in cancer patients.

Purpose of the Study:

  • To elucidate the multifaceted risk factors contributing to cancer-associated thrombosis.
  • To highlight the clinical significance of early diagnosis and treatment of CAT.

Main Methods:

  • Review of clinical data and literature on cancer-associated thrombosis.
  • Analysis of patient-related factors, cancer-specific elements, and treatment-induced effects.
  • Examination of the role of cancer cell-expressed tissue factors and cytokines.

Main Results:

  • CAT risk is multifactorial, involving patient status, cancer type, and anticancer therapies.
  • Anticancer agents can induce vascular endothelial damage, promoting thrombus formation.
  • CAT is a major independent predictor of poor outcomes in cancer patients.

Conclusions:

  • Understanding the complex etiology of CAT is essential for risk stratification.
  • Prompt identification and management of CAT are critical for improving cancer patient survival.
  • Further research into preventative and therapeutic strategies for CAT is warranted.