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Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

54
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
54
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

32
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
32
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
33
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

30
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
30
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

31
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
31
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

32
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
32

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Updated: Sep 9, 2025

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
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Gout, Uric Acid, and Coronary Artery Disease.

Takuya Nakahashi1, Hayato Tada2, Kenji Sakata2

  • 1Division of Cardiology, Department of Internal Medicine, Takaoka City Hospital.

Journal of Atherosclerosis and Thrombosis
|August 31, 2025
PubMed
Summary
This summary is machine-generated.

High serum uric acid (hyperuricemia) is linked to cardiovascular disease and mortality. Identifying patients who benefit from uric acid reduction is crucial for managing residual cardiovascular risk.

Keywords:
Coronary artery diseaseDual energy computed tomographyGoutHyperuricemiaMonosodium urate crystalPercutaneous coronary interventionUric acid

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Area of Science:

  • Cardiology
  • Biochemistry
  • Rheumatology

Background:

  • Hyperuricemia, defined as serum uric acid (UA) >7.0 mg/dL, is a precursor to gout.
  • It is associated with hypertension, diabetes, dyslipidemia, and increased mortality.
  • Elevated UA correlates with atherosclerosis markers and endothelial dysfunction, suggesting a pathogenic link to cardiovascular events.

Purpose of the Study:

  • To review current understanding of hyperuricemia in coronary artery disease (CAD).
  • To discuss future perspectives for managing hyperuricemia as a residual risk factor in CAD patients.

Main Methods:

  • Literature review of current evidence on hyperuricemia and cardiovascular disease.
  • Analysis of pathogenic links between elevated UA and adverse cardiovascular events.
  • Examination of gout, monosodium urate (MSU) crystal deposition, and cardiovascular implications.

Main Results:

  • Hyperuricemia is linked to increased cardiovascular disease (CVD) rates and mortality.
  • MSU crystal deposition can occur in coronary arteries, not just joints.
  • Current urate-lowering therapies lack proven efficacy in reducing cardiovascular events for hyperuricemia.

Conclusions:

  • Hyperuricemia represents a significant residual risk in patients with CAD.
  • Identifying specific patient subgroups who benefit from UA reduction is critical.
  • Further research is needed to establish effective management strategies for hyperuricemia in CAD.