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Single cell-RNA sequencing reveal TOP2A as a key driver of hepatocellular carcinoma progression

Lian Xie1, Fangyin Xu1, Ruixin Shi1

  • 1Wenzhou Medical University, Wenzhou, China.

Scientific Reports
|August 31, 2025
PubMed
Summary

Topoisomerase II alpha (TOP2A) is upregulated in hepatocellular carcinoma (HCC) and drives tumor progression. Knockdown of TOP2A inhibits HCC cell proliferation, migration, and invasion, offering a potential therapeutic target for HCC treatment.

Keywords:
BiomarkerHCCTOP2A

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