LncRNA ADAMTS9-AS1 regulates the proliferation, migration, and invasion of esophageal cancer cells via miR-575/ CADM2
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View abstract on PubMed
Summary
This summary is machine-generated.Long non-coding RNA ADAMTS9-AS1 impacts esophageal squamous cell carcinoma (ESCC) progression by regulating the miR-575/CADM2 axis. This lncRNA shows potential as a prognostic biomarker and therapeutic target for ESCC.
Area Of Science
- Oncology
- Molecular Biology
- Genetics
Background
- Esophageal squamous cell carcinoma (ESCC) is a globally lethal cancer.
- Understanding molecular mechanisms driving ESCC is crucial for public health.
Purpose Of The Study
- Investigate the role of long non-coding RNA (lncRNA) ADAMTS9-AS1 in ESCC.
- Determine how ADAMTS9-AS1 regulates the miR-575/CADM2 axis in ESCC cells.
Main Methods
- Quantitative real-time PCR (qPCR) for gene expression analysis.
- Correlation analysis and survival analysis (Kaplan-Meier, Cox model).
- Functional assays (CCK-8, Transwell) to assess cell proliferation, migration, and invasion.
Main Results
- ADAMTS9-AS1 and CADM2 expression decreased in ESCC, while miR-575 increased.
- ADAMTS9-AS1 expression correlated with TNM staging and lymph node metastasis.
- Overexpression of ADAMTS9-AS1 inhibited ESCC cell proliferation, migration, and invasion, effects reversed by miR-575 co-overexpression.
Conclusions
- ADAMTS9-AS1 targets miR-575/CADM2, influencing ESCC cell function and progression.
- ADAMTS9-AS1 is a potential prognostic biomarker and therapeutic target for ESCC.
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