The Association of IL-17RC Polymorphisms rs708567 and rs76999397 With Acute Lymphoblastic Leukaemia

Acute lymphoblastic leukaemia (ALL) is characterized by the clonal proliferation of immature lymphoid precursors in the bone marrow or peripheral blood. This study investigates whether genetic polymorphisms in IL-17RC are associated with an increased risk of ALL in the Saudi population.

This case-control study included 95 patients with ALL and 95 matched controls. Genetic polymorphisms and their associations with ALL risk were identified using logistic regression analysis. Additionally, quantitative real-time polymerase chain reaction (qRT-PCR) was used to assess the level of IL-17RC mRNA.

The results revealed that carriers of the GA and AA genotypes of rs76999397 had a significantly increased risk of ALL (GA: odds ratios [OR] = 63.78, 95% confidence interval [CI] = 25.51-159.43, p < 0.0001; AA: OR = 18.22, 95% CI = 1.50-221.37, p < 0.0001). Additionally, we identified that an increased risk of ALL was associated with two haplotypes in IL-17RC, C-A and T-A (in the order of rs708567 and rs76999397) (OR = 46.73, 95% CI = 17.30-126.28; OR = 49.42, 95% CI = 6.95-351.45, respectively).

The results suggested that the GA and AA genotypes of rs76999397 were significantly associated with an increased risk of ALL, whereas rs708567 did not show a significant association. Furthermore, the CA and TA haplotypes (rs708567/rs76999397) were found to be associated with increased susceptibility to ALL.