Neuroimaging genetics and developmental psychopathology: A systematic review

Imaging genetics is an interdisciplinary field that integrates neuroimaging and genetic data to improve behavioral prediction and investigate the genetic bases of brain structure and function. It aims to identify associations between genetic markers and brain imaging phenotypes, with a behavioral or clinical trait as the outcome of interest. Since its emergence nearly 30 years ago, the field has advanced substantially, fueled by rapid developments in molecular-genetic and neuroimaging techniques. These advances have opened new avenues for exploring individual differences in cognitive and socio-emotional development and their links to neurodevelopmental disorders. This systematic review examined studies published between 2020 and 2024, focusing on developmental psychopathology. We screened 769 articles from PubMed/MEDLINE and PsycINFO and selected 42 publications that met specific inclusion criteria for review. The studies were categorized into three groups based on the developmental ages in which conditions typically develop: birth/early childhood, late childhood or early adolescence, and late adolescence. Although the field has seen considerable progress, multiple challenges in data acquisition, analysis, and interpretation remain. Larger sample sizes and novel analytical techniques are crucial for the continued advancement of imaging genetics, with animal studies offering potential complementary insights.