Evaluating the Efficacy and Safety of Deoxycholic Acid Injection in Reduction of Flank Fat

Deoxycholic acid (DCA) injection is a noninvasive method for localized fat reduction, offering lower risks compared to invasive techniques. This study evaluates the safety and efficacy of DCA injections for reducing flank fat.

We assessed the efficacy and safety of DCA injections for flank fat reduction over a 12-week period using imaging, anthropometric data, Global Aesthetic Improvement Scale (GAIS) scoring, participant satisfaction, and standardized adverse event reporting.

Adults aged 21-65 years with mild to moderate flank fat (≥ 2 cm) received two sessions of 10 mg/mL DCA injections, 6 weeks apart. Standardized ultrasound and caliper measurements were performed prior to each session. Injections were administered at 0.1-0.15 mL per 1 × 1 cm² area, with a maximum of 2 mL per flank per session, following standardized marking and injection protocols.

Thirty participants (mean age 34.9 years; 86.7% female) completed the study. By Week 12, 86.7% showed aesthetic improvement based on GAIS score, with significant reductions in waist circumference and fat thickness (measured using caliper and ultrasound; p < 0.001). The procedure was generally safe, with most adverse events being mild to moderate and limited to the injection site.

DCA injections effectively reduced localized flank fat after two treatment sessions, resulting in significant aesthetic improvements. Adverse events were mostly mild and manageable, with no serious complications.