Related Experiment Video

Updated: Sep 9, 2025

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
08:37

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Published on: April 21, 2015

16.8K

Early-onset enterocolitis and concerning for macrophage activation syndrome in NLRC4 p.Val342Ala: IL-18 insights

Daigo Kato1, Yoshitake Sato1, Kanako Mitsunaga1

  • 1Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba City, Chiba, Japan.

Pediatrics International : Official Journal of the Japan Pediatric Society
|September 1, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
NLRC4Val342Alaautoinflammatory infantile enterocolitisinterleukin‐18macrophage activation syndrome

More Related Videos

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
05:39

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

3.7K
Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
06:57

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Published on: September 18, 2016

9.1K

Related Experiment Videos

Last Updated: Sep 9, 2025

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
08:37

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Published on: April 21, 2015

16.8K
A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
05:39

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

3.7K
Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
06:57

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Published on: September 18, 2016

9.1K

Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

316
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
316
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

540
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
540

Articles linked to this work by shared authors, journal, and citation graph.

A genotype-first approach reveals the molecular basis of pyrin inflammasome activation.

Science immunology·2026

An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation.

Science immunology·2026

Thalidomide for CGD-related inflammatory bowel disease: A randomized, double-blind trial.

Journal of human immunity·2026

Anti-Integrin αvβ6 Autoantibodies as Diagnostic and Monitoring Biomarkers for Pediatric-Onset Primary Sclerosing Cholangitis.

Hepatology research : the official journal of the Japan Society of Hepatology·2026

A PI(3,5)P2/CHMP4B axis on lysosomes is essential for microautophagic degradation of STING.

Nature communications·2026

Single-cell analysis reveals cell death as driver of NLRP3-mediated secretion of IL-1β in human monocytes.

Nature immunology·2025

Comparison of Phenol Application and Endoscopic Pilonidal Sinus Treatment in Pediatric Pilonidal Sinus Disease.

Pediatrics international : official journal of the Japan Pediatric Society·2026

Outcomes and Regional Care Patterns of Critically Ill Pediatric Emergency Patients: A Population-Based Registry Study.

Pediatrics international : official journal of the Japan Pediatric Society·2026

Characteristics of Pediatric Patients With Home Mechanical Ventilation in a Japanese Regional Core Hospital.

Pediatrics international : official journal of the Japan Pediatric Society·2026

Inspiratory Muscle Training in Children With Cerebral Palsy: Effects on Respiratory and Motor Functions.

Pediatrics international : official journal of the Japan Pediatric Society·2026

Limited Clinical Associations of Age-Adjusted Serum Thymus and Activation-Regulated Chemokine in Kawasaki Disease.

Pediatrics international : official journal of the Japan Pediatric Society·2026

Loci Associated With Susceptibility to Biliary Atresia-A Genome-Wide Association Study in Taiwan.

Pediatrics international : official journal of the Japan Pediatric Society·2026

The Role of Immunosuppression in Ex Vivo Lung Perfusion: A Systematic Review.

Transplantation proceedings·2026

T-cell immunity in human herpesvirus vaccine development: research advances and translational challenges.

Vaccine·2026

Pigeon employs a conserved IRF7 gene to mediate innate immune response.

Poultry science·2026

PTEN restricts infectious bursal disease virus replication through modulating the AKT-TBK1-mediated type I IFN pathway.

Poultry science·2026

Genome-wide identification and comparative analysis of Leucine-Rich Repeat Containing (LRRC) gene and their expression responses to Vibrio alginolyticus infection in the Manila clam (Ruditapes philippinarum).

Comparative biochemistry and physiology. Part D, Genomics & proteomics·2026

Herpesviruses hijack ISGylation to promote viral capsid assembly.

Science advances·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us