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Synthesis and unusual reactivity of (1,5)pyrimidino(6,9)purinophane
Nucleic Acids Symposium Series
|January 1, 1985
Abstract:
In order to elucidate the driving force of the unusual high reactivity of (1,3)pyrimidino(6,9)purinophanes 2 toward nucleophiles at 6-position, title compound 1 is synthesized. It is concluded on the basis of the similar unusual behavior of 1 to 2 that the stereoelectronic effect in the fairly rigid tetrahedral intermediate is responsible for the high reactivity of 1 and 2.