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Related Concept Videos

  1. Home
  3. Research Domains
  5. Biological Sciences
  7. Industrial Biotechnology
  9. Bioprocessing, Bioproduction And Bioproducts
  11. Comprehensive Teaching And Learning Approach For Bioprocess Integration: A Case Study In Chromoprotein Bioproduction.
  1. Home
  3. Research Domains
  5. Biological Sciences
  7. Industrial Biotechnology
  9. Bioprocessing, Bioproduction And Bioproducts
  11. Comprehensive Teaching And Learning Approach For Bioprocess Integration: A Case Study In Chromoprotein Bioproduction.

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Comprehensive Teaching and Learning Approach for Bioprocess Integration: A Case Study in Chromoprotein Bioproduction.

Rigel Valentín Gómez-Acata1, Ana Laura Torres-Huerta1, Juan Silvestre Aranda-Barradas1

  • 1Tecnologico de Monterrey, School of Engineering and Sciences, Atizapán, Mexico.

Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology
|September 1, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

This study introduces a holistic bioprocess design approach for undergraduate biotechnology education, integrating molecular biology, upstream/downstream processing, and economic evaluation for biomolecule production. Students gained comprehensive skills in lab-scale chromoprotein production and bioprocess evaluation.

Keywords:
Benchling application to an industrial strainSuperPro designerholistic bioprocess designindustrial biotechnology

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Area of Science:

  • Biotechnology Engineering
  • Biochemical Engineering
  • Industrial Biotechnology

Background:

  • Bioprocess design education often lacks integrated approaches, focusing heavily on molecular aspects.
  • Key elements like lab-scale production, purification, and economic evaluation are frequently overlooked in academic programs.
  • There is a need for comprehensive training in holistic bioprocess development for industrial biomolecule production.

Purpose of the Study:

  • To propose and assess a comprehensive educational strategy for holistic bioprocess development in undergraduate biotechnology programs.
  • To integrate molecular biology, upstream/downstream processing, and economic evaluation into a cohesive learning experience.
  • To enhance student skills in designing and evaluating bioprocesses for industrial biomolecule production, using recombinant protein (chromoprotein) as a case study.
problem‐solving/decision making in bioprocess design

Main Methods:

  • Developed a curriculum integrating genetic engineering of Escherichia coli, upstream/bioreactor technology, and tailored downstream purification.
  • Implemented a collaborative project focused on recombinant chromoprotein production across multiple Biotechnology Engineering courses.
  • Utilized specialized software (Benchling, MATLAB, SuperPro Designer) for recombinant technology, process modeling, and economic analysis.

Main Results:

  • Students achieved a comprehensive understanding of lab-scale chromoprotein production.
  • Significant skill development was observed in genetic engineering, biomolecule production, bioreactor scaling, and upstream/downstream process selection.
  • Integration of software tools enhanced student confidence and proficiency in bioprocess evaluation and sizing, highlighting the importance of chromatography.

Conclusions:

  • The proposed holistic educational strategy effectively improved students' ability to design and evaluate bioprocesses.
  • This integrated approach better prepares future biotechnology engineers for industrial challenges in economic and sustainable biomolecule production.
  • The study underscores the value of hands-on projects and specialized software in biotechnology education.