Related Experiment Video

Updated: Sep 9, 2025

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
09:36

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

67

Progression of carotid plaque burden in patients with polycythemia vera and essential thrombocythemia

Seong Soon Kwon1, Sun Young Jeong2, Min-Young Lee2

  • 1Division of Cardiology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea.

Blood Research
|September 1, 2025
PubMed

Insights

Carotid plaque burden persists in patients with polycythemia vera (PV) and essential thrombocythemia (ET). Achieving a complete hematologic response (CHR) may prevent worsening of carotid plaque burden in these high-risk patients.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Diagnostic Imaging

Background:

  • Vascular event prevention is crucial for polycythemia vera (PV) and essential thrombocythemia (ET) patients.
  • Carotid ultrasonography (USG) is a valuable tool for cardiovascular and stroke risk stratification.
  • Previous research indicated higher carotid plaque burden in PV/ET patients compared to the general population.

Purpose of the Study:

  • To investigate changes in carotid plaque burden over time in patients diagnosed with PV or ET.
  • To assess the impact of hematologic response on carotid plaque progression in PV/ET patients.

Main Methods:

  • Retrospective analysis of medical records for patients with ET/PV who underwent at least two carotid USG examinations.
  • Evaluation of carotid plaque scores from initial and follow-up USG procedures.

Main Results:

  • A statistically significant increase in carotid plaque score was observed between initial and follow-up USG (p=0.0139).
  • Carotid plaque burden did not significantly differ in patients achieving a complete hematologic response (CHR).
  • Patients failing to achieve CHR showed a significant worsening of carotid plaque burden.

Conclusions:

  • Carotid plaque burden is persistent in patients with PV and ET during follow-up.
  • Achieving a complete hematologic response (CHR) may be a protective factor against the progression of carotid plaque burden in PV/ET patients.
Abstract

Keywords:
Carotid plaque burdenEssential thrombocythemiaPolycythemia vera

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