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Lindenane-Based Sesquiterpenoid Hetero-Oligomers with Diverse Skeletons and Extracellular Regulated Protein Kinases
Danyang Zhang1, Zhiqi Xiao1, An Huang1
1Basic Medical Research Innovation Center for Anti-Cancer Drugs, MOE and Jiangsu Key Laboratory of Bioactive Natural Product Research, China Pharmaceutical University, 639 Longmian Dadao Nanjing 211198, China.
Abstract:
Sarcglabtenes A-G (1-7), seven lindenane-based sesquiterpenoid hetero-oligomers with six unprecedented skeletons, along with five new biosynthetic analogues sarcglabtenes H-L (8-12), were isolated from Sarcandra glabra. Their structures including absolute configurations were comprehensively elucidated using HR-MS, NMR, ECD, and single crystal X-ray diffraction. Structurally, sarcglabtenes A-G are lindenane hetero-oligomers including a geranyl homogentisic acid (1/2), geranylgeranyl p-toluquinone (3/4), germarane (5), campholenal (6/7) derivatives, for which plausible biosynthesis pathways are also proposed. In bioassays, 1-4 exhibited cytotoxic activity against five cancer cell lines, and in particular, 4 acted as extracellular-regulated protein kinase (Erk) inhibitor of the MAPK signaling pathway involved in apoptosis.
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