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Three undescribed Schinortriterpenoids from Schisandra chinensis and their neuroprotective effects
Yan-Li Zhang1, Peng Jiang2, Wu-Yan Chen3
1Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Fitoterapia
|September 1, 2025
Abstract:
Three undescribed SNTs, schisaterpene SU (1-3), were isolated from the extract of Schisandra chinensis. Their structures were elucidated on the basis of HR-ESI-MS, NMR data and ECD calculation. All compounds were evaluated for their Neuroprotective activity induced by MPP+ in SH-SY5Y cells. Notably, compounds 1-3 exhibited significant neuroprotective activity, with EC50 values of 4.46 ± 0.30, 2.76 ± 0.09 and 3.99 ± 0.19 μM for SH-SY5Y cells.

