Related Experiment Video
Updated: Sep 9, 2025
Human Liver Spheroids from Peripheral Blood for Liver Disease Studies
Published on: January 27, 2023
Granulomatous liver disease in a referral center in Mexico city
Jesús Ruiz-Manríquez1, Sandra M Feria-Agudelo2, Antonio Olivas-Martinez3
1Departamento de Gastroenterología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Vasco de Quiroga 15, Belisario Domínguez Secc. 16, Tlalpan, 14080 Ciudad de México, Mexico; Departamento de Medicina Interna, Hospital General Dr. Manuel Gea González, Calz. de Tlalpan 4800, Belisario Domínguez Secc. 16, Tlalpan, 14080 Ciudad de Mexico, Mexico.
Introduction And Objectives:
Up to 15 % of liver biopsies may reveal granulomas. The underlying causes vary geographically, with marked differences between high- and low-middle-income countries. No studies have examined the etiology of granulomatous liver disease (GLD) in Mexico. This study aims to describe the etiologic profile and clinical outcomes of patients diagnosed with GLD at a tertiary care center in Mexico.
Materials And Methods:
Retrospective cohort study of patients diagnosed with GLD by liver biopsy between 2001 and 2017.
Results:
We identified 133 patients with GLD. The most common causes were infectious diseases (36.1 %, n = 48; including 22 mycobacterial infections), foreign body reactions (21.1 %, n = 28), and autoimmune disorders (15.0 %, n = 20). The overall 6-month survival probability was 90.9 % (95 % confidence interval [CI], 86-95 %), declining to 87.5 % (95 % CI, 82-93 %) at 12 months. Patients with autoimmune etiologies had the best prognosis (100 % survival at 6 and 12 months). In contrast, patients with neoplastic GLD had the poorest outcomes, with survival probabilities of 72.7 % (95 % CI, 50.6-100 %) at 6 months and 63.6 % (95 % CI, 40.7-99.5 %) at 12 months. Patients with idiopathic GLD had a favorable short-term prognosis, with a 12-month survival probability of 92 %.
Conclusions:
In this cohort, infectious diseases were the most common cause of GLD. Prognosis varied by etiology, with idiopathic cases showing favorable short-term outcomes and neoplastic cases exhibiting poor survival rates.
