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Updated: Sep 9, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

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YY1-induced USP43 drives ferroptosis suppression by FASN stabilization and subsequent activation of SLC7A11 in

Tianyi Zhao1,2,3, Xiaojun Chen1,3, Jiangchun Wu1,3

  • 1Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Cell Death & Disease
|September 1, 2025
PubMed

Insights

Ubiquitin-specific protease 43 (USP43) promotes ovarian cancer by suppressing ferroptosis via the FASN-HIF1α-SLC7A11 pathway. Targeting this axis may improve platinum sensitivity in ovarian cancer.

Area of Science:

  • Oncology
  • Biochemistry
  • Molecular Biology

Background:

  • The ubiquitin-specific protease (USP) family plays diverse roles in cancer.
  • The specific functions of USP family members in ovarian cancer remain largely unelucidated.

Purpose of the Study:

  • To screen USP family expression in ovarian cancer.
  • To investigate the role and mechanism of USP43 in ovarian cancer progression and ferroptosis.

Main Methods:

  • Bioinformatic analysis of USP family expression.
  • In vitro and in vivo functional assays (cell viability, ferroptosis, xenograft models).
  • Exploration of the USP43-FASN-HIF1α-SLC7A11 signaling axis.

Main Results:

  • USP43 overexpression is linked to poor prognosis in ovarian cancer.
  • USP43 promotes ovarian cancer progression by suppressing ferroptosis via the FASN-HIF1α-SLC7A11 pathway.
  • USP43 stabilizes FASN, which in turn stabilizes HIF1α, leading to SLC7A11 expression.

Conclusions:

  • USP43 is a key driver of ovarian cancer progression and ferroptosis suppression.
  • Targeting the USP43-FASN-HIF1α-SLC7A11 axis offers a potential therapeutic strategy.
  • Combination therapy with cisplatin and SLC7A11 inhibitors shows promise for ovarian cancer treatment.

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