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Related Experiment Video

Updated: Sep 9, 2025

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

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Published on: January 8, 2020

ONMR: an orthopedic and nutritional Mendelian randomization database.

Zikun Chen¹, Xuequan Hou², Binyu Chen¹

¹Institute of Orthopaedics and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China.

NPJ Science of Food

|September 1, 2025

Summary

The largest Mendelian Randomization platform, ONMR, reveals how diet impacts bone health, showing age-dependent effects. This resource aids precision medicine in nutrition and orthopedics.

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Last Updated: Sep 9, 2025

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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

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Published on: June 21, 2018

Area of Science:

Orthopedics
Nutritional Science
Genetics
Precision Medicine

Background:

Skeletal health is influenced by age and nutrition.
Existing research on diet and orthopedic diseases lacks systematic analysis.
A comprehensive framework is needed to understand diet-skeletal health interactions.

Purpose of the Study:

To develop the largest platform, ONMR, for Mendelian Randomization analysis.
To investigate the impact of dietary intake on orthopedic disorders.
To provide a comprehensive framework for diet-skeletal health interactions.

Main Methods:

Utilized Mendelian Randomization (MR).
Integrated Genome-Wide Association Study (GWAS) data.
Performed over 100,000 analyses linking 210 nutrients to 503 bone phenotypes.

Main Results:

Elucidated dual effects of dietary intake on bone health.
Identified age-dependent characteristics of dietary impacts.
Established ONMR as a comprehensive resource for diet-orthopedic research.

Conclusions:

ONMR provides a pivotal resource for interdisciplinary research.
Findings contribute to understanding complex diet-skeletal health interactions.
The platform supports advancements in precision medicine for skeletal health management.