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The association between the BRI and all-cause and cardiovascular mortality in COPD patients
Riken Chen1, Yuli Cai1, Qinghua Chen1
1The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524003, China.
Insights
The Body Roundness Index (BRI) is linked to higher mortality in chronic obstructive pulmonary disease (COPD) patients. Higher BRI scores indicate increased risk for all-cause and cardiovascular death in COPD.
Area of Science:
- Pulmonary Medicine
- Cardiology
- Biostatistics
Background:
- Waist circumference is associated with COPD exacerbations.
- The prognostic value of Body Roundness Index (BRI) in COPD patients is not well understood.
Purpose of the Study:
- To investigate the association between BRI and all-cause and cardiovascular mortality in COPD patients.
- To evaluate BRI's predictive performance for mortality in this population.
Main Methods:
- Analysis of 3,672 COPD participants from NHANES (1999-2018).
- Utilized multivariable Cox proportional hazards models, Kaplan-Meier analysis, and restricted cubic spline analyses.
- Assessed BRI's predictive accuracy using ROC curves and conducted subgroup analyses.
Main Results:
- BRI was significantly associated with increased all-cause and cardiovascular mortality.
- Higher BRI quartiles correlated with reduced survival and increased cumulative mortality.
- BRI demonstrated superior predictive performance for mortality compared to other models.
Conclusions:
- BRI is a significant predictor of mortality in COPD patients.
- Elevated BRI is linked to higher risks of all-cause and cardiovascular death.
- BRI may serve as a target for interventions to reduce mortality in COPD.
Objective:
Waist circumference (WC) has been linked to exacerbations in chronic obstructive pulmonary disease (COPD), but the relationship between WC, height, and the Body Roundness Index (BRI) with mortality in COPD patients remains unclear. This study investigates the association between BRI and both all-cause and cardiovascular mortality in COPD patients.
Methods:
Data from 3,672 COPD participants (1,517 men and 2,155 women; mean age: 53.17 ± 16.46 years) were obtained from NHANES (1999-2018). Multivariable Cox proportional hazards models, Kaplan-Meier analysis, Nelson-Aalen cumulative hazard plots, and restricted cubic spline analyses were used to assess the relationship between BRI and mortality. ROC curves were constructed to evaluate BRI's predictive performance. Subgroup and sensitivity analyses ensured robustness of the models.
Results:
The BRI was associated with all-cause (HR: 1.12, 95% CI: 1.05-1.19) and cardiovascular mortality (HR: 1.14, 95% CI: 1.01-1.29). Kaplan-Meier curves and Nelson-Aalen plots demonstrated that higher BRI quartiles correlated with lower survival probabilities and increased cumulative mortality incidence. ROC curve analysis showed that BRI outperformed other models in predicting all-cause [AUC: 0.81 (0.79-0.82)] and cardiovascular mortality [AUC: 0.79 (0.76-0.81)]. A significant interaction was observed between BRI and alcohol consumption for all-cause mortality. Results remained consistent after excluding participants who died within two years (HR: 1.10, 95% CI: 1.03-1.18) and in the alcohol-consuming subgroup (HR: 1.14, 95% CI: 1.05-1.24).
Conclusion:
The BRI is associated with increased all-cause and cardiovascular mortality in COPD patients, with higher BRI quartiles linked to greater mortality risk. Targeting BRI may offer a potential strategy to reduce mortality in this population.
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