Related Experiment Video
Updated: Sep 9, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Knowledge translation platforms: Broker, intermediary or more? A scoping review of definitions, functions and
B Schmidt1,2,3, C Mulopo4,5, L Mayieka6
1Health Systems Research Unit, South African Medical Research Council, Cape Town, South Africa. Bey-Marrie.Schmidt@mrc.ac.za.
Background:
Knowledge translation platforms (KTPs), also referred to as intermediaries, play a key role in supporting evidence-informed decision-making. Numerous KTPs exist globally, striving to translate evidence into policy. However, these platforms are described in varying ways, and some KTPs do not explicitly identify themselves as such. This makes identification, recognition and leveraging of KTPs suboptimal. It also hinders opportunities for learning, adapting and scaling of such platforms.
Objective:
This scoping review aimed to synthesize the literature on the variety of definitions, functions and characteristics of a KTP with a view to harmonize these aspects of KTPs and offer a revised framework of functions.
Methods:
This review was conducted using recommended methods and reporting guidelines. Searches were performed in PubMed, Scopus and Cumulative Index to Nursing and Allied Health Literature (CINAHL) using a predetermined search strategy, without date or geographical restrictions. Included studies were analysed and synthesized in ATLAS.ti, following Braun and Clarke's six steps of thematic analysis.
Findings:
With one exception, all KTPs did not identify themselves as such in their names. Five common elements emerged across the KTP definitions: (i) a physical or virtual platform (ii) that engages with and convenes different stakeholders (iii) through a set of knowledge translation activities and outputs (iv) to contribute to health decision-making. We identified KTP activities that aligned with the core functions described in the Valmeekanathan et al. (Valmeekanathan et al. in Tert Educ Manag 27:227-256, 2021) framework - namely knowledge exchange, dialogue and capacity - but also additional activities, including engaging funders, planning for sustainability and scalability, providing training grants and initiating innovative knowledge translation processes that integrate knowledge across projects and sectors to maximize impact.
Conclusion:
This review provides a synthesized definition of KTPs while expanding on the three core functions described in the Valmeekanathan et al. (Valmeekanathan et al. in Tert Educ Manag 27:227-256, 2021) framework. To maximize their impact, sustained investment, stronger institutional support and integration into national policy ecosystems are essential.
Related Concept Videos
Leaky Scanning
Improving Translational Accuracy
Bioequivalence: Overview
Ribosome Profiling
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
Translational Regulation
Riboswitches
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...

