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Diabetic retinopathy screening using machine learning: a systematic review
Fitsum Mesfin Dejene1, Taye Girma Debelee2,3, Friedhelm Schwenker4
1Computer Vision, Ethiopian Artificial Intelligence Institute, Addis Ababa, 40782, Ethiopia.
BMC Biomedical Engineering
|September 2, 2025
Summary
Machine learning (ML) offers a promising alternative for diabetic retinopathy (DR) screening, addressing limitations in manual image analysis. This study analyzes ML integration in DR screening, identifying challenges and future research directions.
Area of Science:
- Ophthalmology
- Medical Imaging
- Artificial Intelligence
Background:
- Diabetic retinopathy (DR) is a leading cause of blindness globally.
- Manual screening of retinal images is time-consuming and faces expert shortages.
- Machine learning (ML) and deep learning (DL) present viable alternatives for DR screening.
Purpose of the Study:
- To analyze the research landscape of ML integration in diabetic retinopathy screening.
- To identify and characterize available retinal fundus image datasets.
- To discuss preprocessing techniques, ML progress, challenges, and future directions in DR screening.
Main Methods:
- Literature review and analysis of ML techniques applied to DR screening.
- Characterization of publicly available retinal fundus image datasets.
- Discussion of common image preprocessing methods for DR detection.
Main Results:
- Identified and characterized available retinal image datasets for DR screening.
- Analyzed the progress and application of various ML techniques in DR detection.
- Highlighted common preprocessing steps essential for effective DR screening.
Conclusions:
- ML integration shows significant potential to improve the efficiency and accessibility of diabetic retinopathy screening.
- Standardized datasets, model complexity, and computational resources remain key challenges.
- Further research is needed to overcome existing hurdles and advance ML-based DR screening solutions.

