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Systematic Review and Meta-Analysis of Acupuncture Treatment for Diabetic Cognitive Impairment: Focus on Animal
Xinyi Jiao1, Yue Hu2, Guoqing Tian1
1Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background:
Cognitive impairment is a frequent complication of diabetes, yet effective treatments remain elusive. In animal models, acupuncture has shown potential in improving cognitive deficits related to diabetes, but a comprehensive evaluation of its efficacy is lacking.
Materials And Methods:
We systematically searched seven databases (PubMed, Web of Science, Embase, OVID, SinoMed, CNKI, and Wanfang) from their inception through January 1, 2025. Studies meeting inclusion criteria underwent quality assessment using the SYRCLE Risk of Bias tool. Data analysis was conducted with Stata 14.0.
Results:
Thirteen studies comprising 294 animals were included. Acupuncture significantly reduced blood glucose in diabetic models [SMD = -2.44, 95% CI (-3.33, -1.55); I2 = 88.9%, p < 0.000], shortened water maze escape latency [SMD = -2.35, 95% CI (-2.86, -1.84); I2 = 60.0%, p = 0.003], and increased target platform crossings [SMD = 1.49, 95% CI (1.10, 1.88); I2 = 51.9%, p < 0.001].
Conclusion:
Acupuncture can improve cognitive impairment in diabetic animal models and lower their blood glucose levels.
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