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Whole Brain Amide Proton Transfer Weighted Imaging in Children With Obstructive Sleep Apnea

Guisen Lin1, Weiting Tan1, Shaojun Zhang2

  • 1Department of Radiology, Shenzhen Children's Hospital, Shenzhen, China.

Brain and Behavior
|September 2, 2025
PubMed

Insights

Brain imaging reveals altered amide proton transfer weighted (APTw) signals in children with obstructive sleep apnea (OSA), linking these changes to cognitive impairments. APTw may detect brain damage in OSA patients.

Area of Science:

  • Neuroimaging
  • Pediatric Sleep Medicine
  • Cognitive Neuroscience

Background:

  • Obstructive sleep apnea (OSA) in children is associated with cognitive deficits.
  • Amide proton transfer weighted (APTw) imaging is a sensitive MRI technique for detecting subtle brain tissue alterations.

Purpose of the Study:

  • To investigate alterations in brain APTw signals in children with OSA.
  • To assess the relationship between APTw signal changes in specific brain regions and cognitive function in pediatric OSA.

Main Methods:

  • Prospective study comparing 46 children with OSA and 20 controls using whole-brain APTw MRI.
  • Statistical analysis included Fisher's LSD, Kruskal-Wallis, and Steel-Dwass tests for group comparisons.
  • Pearson's or Spearman's correlation analyses examined the association between APTw signals and cognitive scores.

Main Results:

  • Children with mild OSA showed lower white matter APTw signals in the inferior frontal gyrus, angular gyrus, and thalamus compared to moderate-severe OSA.
  • Moderate-severe OSA was associated with significantly lower gray matter APTw signals in the supramarginal and lingual gyri, corona radiata, and genu of corpus callosum compared to controls.
  • APTw signals in frontal-parietal-temporal regions, hippocampus, and corona radiata correlated significantly with cognitive assessment scores.

Conclusions:

  • APTw imaging can identify brain regions, including the frontal-parietal-temporal areas and hippocampus, affected in children with OSA.
  • These APTw signal alterations may underlie the cognitive impairments observed in pediatric OSA.
Abstract

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