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Related Concept Videos

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Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Related Experiment Video

Updated: Sep 9, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Cancer Cell Detection and Precision Targeting Drug Delivery by Covalently Functionalized Liposome.

Malabika Ghosh1, Uddipan Dasgupta1, Sourav Barman2

  • 1Amity Institute of Nanotechnology, Amity University Kolkata, Major Arterial Road, AA II, Newtown, Kolkata, West Bengal 700135, India.

ACS Applied Bio Materials
|September 2, 2025
PubMed
Summary

Folic acid-liposomes (FA-liposomes) show promise for cancer cell detection and targeted drug delivery. This approach enhances therapeutic efficacy by concentrating the anticancer drug Doxorubicin within cancer cells, minimizing harm to healthy tissues.

Keywords:
Biomimetic strategybiosensorfunctionalized liposomesnanocarriertargeted drug deliverytargeting ligand

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Area of Science:

  • Nanomedicine
  • Cancer Diagnostics
  • Drug Delivery Systems

Background:

  • Targeting cancer cells for detection and drug delivery remains a significant challenge.
  • Folic acid, a targeting ligand, binds to folate receptors (FR) overexpressed on cancer cells.
  • Liposomes offer a versatile platform for drug encapsulation and targeted delivery.

Purpose of the Study:

  • To evaluate folic acid-liposomes (FA-liposomes) for selective cancer cell detection.
  • To assess the targeted delivery of Doxorubicin (Dox) using FA-liposomes (FA-Lip-Dox).
  • To investigate the potential of FA-Lip-Dox in cancer treatment with reduced off-target effects.

Main Methods:

  • Covalent conjugation of folic acid to liposomes for enhanced targeting.
  • Encapsulation of Doxorubicin within FA-liposomes to create FA-Lip-Dox.
  • Evaluation of FA-Lip-Dox targeting efficiency and drug delivery in cancerous (U87MG, KB) and noncancerous (CHO) cell lines using fluorescence imaging and flow cytometry.

Main Results:

  • FA-Lip-Dox demonstrated selective targeting and accumulation in FR-overexpressing cancer cells (KB).
  • Significant Doxorubicin penetration was observed in cancerous cells, with negligible accumulation in non-targeting cells.
  • Low cytotoxicity was noted towards normal cells, indicating a favorable safety profile.

Conclusions:

  • FA-Lip-Dox effectively targets cancer cells for both detection and drug delivery.
  • This targeted nanocarrier system maximizes therapeutic efficacy while minimizing toxicity to healthy cells.
  • FA-Lip-Dox holds significant potential for advancing cancer treatment strategies.