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Updated: Sep 9, 2025

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
Reaction of an osmium(VI) nitrido complex with enamines generated in situ from ketones and anilines
Lei Wang1, Li-Xin Wang2, Zhao-Long Liu1,2
1Anhui Research Academy of Ecological and Environmental Sciences, Hefei, 230071, Anhui, P. R. China.
Abstract:
The reaction of [OsVI(N)(L)(CN)3]- (OsN, HL = 2-(2-hydroxy-5-nitrophenyl)-benzoxazole) with a mixture of acetone and 2,4,6-trimethylaniline (MesNH2) affords [OsIII(L)(CN)3(L1)]- (L1 = N-mesityl-2-(mesitylimino)propanimidamide), where L1 is derived from the combination of an acetone molecule, a nitrido ligand, and two MesNH2 units. The reaction of OsN with acetone and the less bulky aniline gives [OsIII(L)(CN)3(L3)]- (L3 = 1,3-diphenylguanidine) and phenylacetamide, where L3 is derived from the combination of three anilines, one acetone, and the nitrido ligand; this reaction results in C-C bond cleavage of acetone. C-C bond cleavage of ketone also occurs in the reaction of OsN with 2-butanone and aniline. Mechanistic studies indicate that the initial step in these reactions is the condensation of the ketone and the amine to give an enamine, which then undergoes nucleophilic addition to OsN.
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