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Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...

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Portable Ratiometric Fluorescence Sensor for Immediate Creatinine Detection in Early Medical Screening.

Zhi Li1,2, Zhengjie Chen2, Rui Wang3

  • 1School of Nursing, Wuhan University, Wuhan, 430072, China.

Advanced Healthcare Materials
|September 2, 2025
PubMed
Summary

A new colorimetric-fluorescent sensor using nitrogen-doped carbon dots and copper nanoclusters offers rapid, accurate detection of urinary creatinine (CR). This low-cost, paper-based sensor aids early kidney disease diagnosis and monitoring.

Keywords:
Cu nanoclusterscreatinine detectionnitrogen‐doped carbon dotspaper‐based sensorspoint‐of‐care diagnostics

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Nanotechnology

Background:

  • Accurate urinary creatinine (CR) detection is vital for early kidney disease screening.
  • Traditional CR measurement methods can be time-consuming and lack portability.
  • Developing rapid, sensitive, and selective diagnostic tools is a priority in healthcare.

Purpose of the Study:

  • To develop a novel colorimetric-fluorescent sensor for sensitive and selective urinary creatinine detection.
  • To integrate nitrogen-doped carbon dots (N-CDs) and copper nanoclusters (CuNCs) with gold nanoparticles (AuNPs) for enhanced sensing capabilities.
  • To create a low-cost, portable, and stable sensor for on-site CR analysis.

Main Methods:

  • Fabrication of a dual-probe sensor system combining N-CDs, CuNCs, and AuNPs.
  • Utilizing fluorescence resonance energy transfer (FRET) for signal amplification.
  • Testing the sensor's performance on paper-based substrates for practical application.
  • Evaluating sensor stability, selectivity, and interference resistance in complex samples.

Main Results:

  • The sensor demonstrated a detection range of 1-50 mm with peak responsiveness at 17 mm.
  • Achieved enhanced sensitivity and selectivity through the synergistic FRET effect of the dual-probe system.
  • The paper-based sensor exhibited excellent stability and strong resistance to interfering substances.
  • The developed sensor showed significantly improved detection accuracy and operational simplicity compared to traditional methods.

Conclusions:

  • The novel N-CDs/CuNCs/AuNPs sensor provides a promising platform for rapid, on-site urinary creatinine analysis.
  • This innovative approach facilitates early diagnosis and effective monitoring of kidney diseases.
  • The sensor's low cost, portability, and high performance offer advantages for diverse clinical and remote settings.