Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Some observations on the kindling process.

H A Robertson, G A Cottrell

    Progress in Neuro-Psychopharmacology & Biological Psychiatry
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Early alterations of functional connectivity, regional brain volumes and astrocyte markers in the beta-sitosterol beta-d-glucoside (BSSG) rat model of parkinsonism.

    Experimental neurology·2024
    Same author

    A new experimental model for the investigation of sequential hermaphroditism.

    Scientific reports·2021
    Same author

    Identified Helix Neurons: Mutually Exclusive Expression of the Tetrapeptide and Heptapeptide Members of the FMRFamide Family.

    The Biological bulletin·2018
    Same author

    Lateralized microstructural changes in early-stage Parkinson's disease in anterior olfactory structures, but not in substantia nigra.

    Journal of neurology·2017
    Same author

    Antisense Therapeutics in the Central Nervous System : The Induction of c-fos.

    Methods in molecular medicine·2011
    Same author

    Structure of cDNA clones and genomic DNA FMRFamide-related peptides (FaRPs) in Helix.

    Molecular and cellular neurosciences·2009
    Same journal

    Single Ayahuasca administration attenuates alcohol relapse and associated behavioral, neurochemical, and oxidative alterations in rats.

    Progress in neuro-psychopharmacology & biological psychiatry·2026
    Same journal

    Altered dorsal striatal subregional connectivity associated with distinct executive function deficits in first-episode, drug-naïve major depressive disorder: Evidence from functional connectivity and granger causality analysis.

    Progress in neuro-psychopharmacology & biological psychiatry·2026
    Same journal

    Chronic pain and stress: unravelling the common neuroinflammatory, immune and endocrine mechanisms for novel therapeutic approaches.

    Progress in neuro-psychopharmacology & biological psychiatry·2026
    Same journal

    Predicting anhedonia and negative cognitive processing changes after 8-week SSRIs treatment in depression from individual differential structural covariance network.

    Progress in neuro-psychopharmacology & biological psychiatry·2026
    Same journal

    Mapping intrinsic neural timescale alterations in major depressive disorder.

    Progress in neuro-psychopharmacology & biological psychiatry·2026
    Same journal

    Probiotics in reducing negative symptoms of schizophrenia: A systematic review and meta-analysis.

    Progress in neuro-psychopharmacology & biological psychiatry·2026
    See all related articles

    Kindling, an epilepsy model, involves permanent brain changes making it sensitive to stimuli. Understanding the critical 1-2 hour inter-stimulus period is key to clarifying its biological basis.

    Area of Science:

    • Neuroscience
    • Epilepsy Research
    • Animal Models of Neurological Disorders

    Background:

    • Kindling is an established animal model for studying epilepsy.
    • It involves repeated subconvulsant stimuli leading to progressively severe electroencephalographic and behavioral responses, culminating in seizures.
    • The underlying biological mechanisms of kindling remain largely unknown, though neurotransmission alterations are frequently hypothesized.

    Purpose of the Study:

    • To explore the permanent biological changes underlying the kindling phenomenon.
    • To investigate the critical inter-stimulus interval (1-2 hours) and its role in the kindling process.
    • To examine the potential for chemical manipulation of the events occurring during this critical period.

    Main Methods:

    • The study discusses the conceptual framework of kindling, emphasizing the permanent nature of the change.

    Related Experiment Videos

  • It reviews hypotheses regarding neurotransmitter levels, receptor parameters, and Ca++ activated mechanisms affecting neuronal structures.
  • It highlights the significance of the inter-stimulus interval and mentions experiments using cysteamine.

    • Main Results:

    • Kindling represents a permanent alteration in brain sensitivity to stimuli, distinct from a kindled seizure itself.
    • Conclusive evidence for permanent changes in neurotransmitter levels or receptor parameters is lacking.
    • Permanent alterations in Ca++ activated mechanisms affecting neuronal structures like dendritic spines are considered possible.

    Conclusions:

    • The biological basis of kindling is a permanent change in brain sensitivity.
    • The 1-2 hour inter-stimulus interval is crucial, suggesting a specific biological process occurs during this time.
    • Chemical manipulation, as suggested by cysteamine experiments, may offer insights into these critical events and the basis of kindling.