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Comparison of the effects of amphetamine and a fluorinated analogue on locomotion and exploratory activity in the

R E Dubin, R J Reiffenstein, G B Baker

Progress in Neuro-Psychopharmacology & Biological Psychiatry

|January 1, 1985

Abstract:

(+)-Amphetamine (AM) and its fluorinated analogue (+)-2-amino-3-fluoro-1-phenylpropane (fluoroamphetamine, FAM) were compared with regard to their effects on locomotor and exploratory activity in mice. Both drugs caused a reduction in spontaneous exploration, but this effect was more marked with FAM than with AM at 1 h after injection. Both compounds increased locomotor activity 10 min after injection, but FAM had sedative effects after 1 h, while AM continued to be stimulatory.

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