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Magnetic fields as environmental specific cues for morphine-induced analgesia: interactions with tolerance
Progress in Neuro-Psychopharmacology & Biological Psychiatry
|January 1, 1985
Summary
Weak fluctuating magnetic fields can increase pain sensitivity and tolerance to morphine in mice. This effect, mediated by the opioid system, suggests magnetic fields act as stressors during tolerance development.
Area of Science:
- Neuroscience
- Pharmacology
- Environmental Health
Background:
- Previous studies show weak fluctuating magnetic fields (WFM) induce environmental specific cues for morphine tolerance.
- WFM exposure also increases basal nociceptive response in animals.
Purpose of the Study:
- To investigate the role of opioid systems in the effects of WFM on nociception and morphine tolerance.
- To explore the stress-mediated mechanisms of WFM as environmental cues.
Main Methods:
- Mice were exposed to WFM to assess tolerance to morphine-induced analgesia.
- Basal nociceptive responses were measured in WFM-exposed and control groups.
- The effect of naloxone, an opiate antagonist, on WFM-induced changes was evaluated.
Main Results:
- WFM exposure led to the development of tolerance to morphine-induced analgesia.
- A significant increase in basal nociceptive response was observed in WFM-exposed mice.
- Naloxone administration blocked the WFM-induced increase in nociceptive response.
Conclusions:
- The findings suggest an opioid-mediated stress effect of WFM stimuli.
- WFM may act as environmental stressors during the acquisition of morphine tolerance.
- Opioid system interactions are implicated in the mechanism of WFM's environmental cueing effects.