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Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation
Published on: October 31, 2019
Bioactive Cyclodepsipeptides from Cocultured Mangrove-Derived Aspergillus sp. and Penicillium sp
Yu Wang1, Guang-Ping Cao1, Xin-Jian Qu2,3,1
1Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, P.R. China.
Abstract:
Three new arthrichitin derivatives I-K (1-3) and three known congeners (4-6) were isolated from a coculture of mangrove-derived fungi Aspergillus sp. and Penicillium sp. using 1H NMR-guided fractionation. Their structures were determined by comprehensive spectroscopic analysis (1D/2D NMR, HRESIMS, ESI-MS/MS), Marfey's analysis, DP4+ probability, and experimental/computed ECD comparison. All compounds were evaluated for antibacterial effects and cytotoxicity. Notably, compounds 1 and 5 showed weak cytotoxicity against MHCC-97H cells (IC50 = 20.1 ± 0.9 and 25.8 ± 0.4 μM, respectively). Compound 4 exhibited potent anti-BPH activity (IC50 = 0.36 ± 0.02 μM).
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