Related Experiment Video
Updated: Sep 9, 2025
Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
Published on: November 5, 2019
Managing penicillin resistant pneumococcal meningitis: an international id-iri study
Hakan Erdem1, Elif Dogan2, Handan Ankarali3
1Department of Infectious Diseases & Clinical Microbiology, Health Sciences University, Gülhane School of Medicine, Ankara, Türkiye. hakanerdem1969@yahoo.com.
Penicillin-resistant pneumococcal meningitis (PRPM) is a severe infection with high mortality and sequelae rates. Early indicators like ICU admission and mechanical ventilation predict worse outcomes, while moxifloxacin shows promising susceptibility.
Area of Science:
- Infectious Diseases
- Clinical Microbiology
- Epidemiology
Background:
- Penicillin-resistant pneumococcal meningitis (PRPM) presents significant clinical challenges and high fatality rates.
- Understanding the clinical features, outcomes, and antimicrobial resistance patterns is crucial for effective management.
Purpose of the Study:
- To evaluate clinical characteristics, outcomes, and predictors of mortality and sequelae in PRPM patients.
- To assess antimicrobial efficacy and drug susceptibility patterns in a global cohort.
Main Methods:
- A multicentre, international retrospective study involving 138 PRPM patients from 33 centers in 11 countries (2019-2024).
- Univariate and multivariate analyses were employed to identify outcome predictors.
- Antibiotic susceptibility testing was performed on bacterial isolates.
Main Results:
- Overall, 60.1% of patients were cured, 19.6% died, and 20.3% survived with sequelae.
- Mortality was associated with ICU admission, mechanical ventilation, and vasopressor use.
- Moxifloxacin demonstrated high susceptibility (97.9%), while ceftriaxone (55.9%) and meropenem (59%) showed lower rates.
Conclusions:
- PRPM remains a life-threatening infection, with nearly two-fifths experiencing mortality or sequelae.
- Severe illness markers and recurrent meningitis are linked to adverse outcomes.
- Corticosteroid therapy may offer a protective effect, and moxifloxacin shows potential for treating PRPM despite resistance challenges.
More Related Videos
09:17A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
Published on: January 2, 2017
11:32Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
Related Concept Videos
01:28Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
01:21Rheumatic Heart Disease III: Medical Management
01:30Pneumonia III: Complications and Assessment
01:28Pleural Effusion II: Symptoms and Management
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
01:30Pneumonia V: Nursing management and Prevention
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....