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Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
Published on: May 10, 2019
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Study of simultaneous bilateral auditory brainstem response recordings based on spread spectrum technology.
Suju Wang1, Jiayan Yang1, Bingya Guo1
1Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
The Journal of the Acoustical Society of America
|September 2, 2025
Summary
Spread spectrum technology enables simultaneous bilateral auditory brainstem response (ABR) testing. This novel approach significantly reduces testing time compared to traditional methods without affecting result accuracy.
Area of Science:
- Audiology
- Neuroscience
- Biomedical Engineering
Background:
- Long testing durations are a significant limitation in clinical auditory brainstem response (ABR) assessments.
- Simultaneous bilateral testing offers a potential solution but faces challenges with binaural interactions.
- Identifying individual ear responses during simultaneous testing requires advanced methodologies.
Purpose of the Study:
- To introduce and evaluate a spread spectrum technology-based simultaneous bilateral ABR (ssBi-ABR) method.
- To compare the effectiveness of ssBi-ABR with traditional unilateral ABR (uABR) testing.
- To assess the impact of ssBi-ABR on testing duration and response accuracy.
Main Methods:
- Application of spread spectrum technology with random stimulus rates for independent bilateral ear stimulation.
- Comparison of ssBi-ABR results against established unilateral auditory brainstem response (uABR) measurements.
- Analysis of response thresholds, latencies, amplitudes, and overall testing time.
Main Results:
- No significant difference in response thresholds between ssBi-ABR and uABR.
- ssBi-ABR exhibited slightly longer latencies and lower amplitudes than uABR, with minimal average differences.
- ssBi-ABR testing duration was significantly reduced, requiring only 63% of the time needed for uABR.
Conclusions:
- Spread spectrum technology facilitates effective simultaneous bilateral ABR testing.
- The ssBi-ABR method significantly shortens audiological testing times.
- This technique maintains the accuracy of ABR results while improving efficiency.

