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Frontiers in Systemic Therapy for Unresectable or Metastatic Adrenocortical Carcinoma: Harnessing Novel Therapeutic

Adam E Singer1, Nikhita Kathuria-Prakash1, David Shabsovich1

  • 1Division of Hematology/Oncology, Department of Internal Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Clinical Medicine Insights. Oncology
|September 2, 2025
PubMed

Insights

Adrenocortical carcinoma treatments are limited. This review covers novel, non-chemotherapy clinical trials for advanced adrenocortical carcinoma, offering new hope beyond traditional therapies.

Area of Science:

  • Endocrinology
  • Oncology
  • Pharmacology

Background:

  • Adrenocortical carcinoma is a rare, aggressive endocrine malignancy.
  • Unresectable or metastatic disease has a poor prognosis.
  • Limited effective systemic therapy options exist, with chemotherapy and mitotane as traditional choices.

Purpose of the Study:

  • To review non-chemotherapeutic approaches for adrenocortical carcinoma.
  • To summarize novel therapies currently in clinical trials.
  • To provide an overview of emerging treatment strategies.

Main Methods:

  • Systematic review of clinical trials.
  • Literature search for non-chemotherapeutic agents.
  • Analysis of ongoing and completed studies.

Main Results:

  • Multiple novel therapeutic approaches are under investigation.
  • These agents target various mechanisms of action.
  • Clinical trials are evaluating efficacy and safety.

Conclusions:

  • Non-chemotherapeutic strategies represent a growing area of research.
  • These novel treatments may offer improved outcomes for adrenocortical carcinoma.
  • Further research is crucial to establish new standards of care.
Keywords:
Adrenocortical carcinomaimmune checkpoint inhibitorsradiopharmaceuticalssystemic therapytyrosine kinase inhibitors

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