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Updated: Sep 9, 2025

Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes
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Enantioselective Pd-Catalysed Nucleophilic C(sp3)-H (Radio)fluorination.

Nikita Chekshin1, Luo-Yan Liu1, D Quang Phan1

  • 1Department of Chemistry, The Scripps Research Institute; 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Nature Catalysis
|September 2, 2025
PubMed
Summary

Researchers developed a novel palladium-catalyzed method for enantioselective C-H fluorination of amides and lactams. This breakthrough enables the synthesis of valuable chiral fluorinated compounds and facilitates 18F-radiolabelling for drug discovery.

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