Related Experiment Video

Updated: May 3, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

23.1K

Molecular Prevalence and Antimicrobial Resistance Profile of Staphylococcus aureus and Staphylococcus

Kazi Shams Al Arefin1, Eaftekhar Ahmed Rana1, Md Saiful Islam1

  • 1Department of Microbiology and Veterinary Public Health, Chattogram Veterinary and Animal Sciences University, Khulshi, Chattogram 4225, Bangladesh.

Veterinary Medicine International
|September 2, 2025
PubMed

Insights

Staphylococcus aureus and Staphylococcus pseudintermedius are common in cats, with high antimicrobial resistance and multidrug resistance (MDR) detected. Previous antibiotic use, otitis externa, and steroid use were identified as risk factors for carriage.

Area of Science:

  • Veterinary Microbiology
  • Companion Animal Health
  • Antimicrobial Resistance

Background:

  • Coagulase-positive staphylococci, including Staphylococcus aureus and Staphylococcus pseudintermedius, are significant pathogens causing suppurative infections in companion animals.
  • Understanding the prevalence and resistance patterns of these bacteria in cats is crucial for effective treatment and infection control.

Purpose of the Study:

  • To determine the molecular prevalence of Staphylococcus aureus and Staphylococcus pseudintermedius carriage in cats.
  • To characterize the antimicrobial resistance profiles and identify multidrug-resistant (MDR) isolates.
  • To investigate risk factors associated with bacterial colonization in feline hosts.

Main Methods:

  • Cross-sectional study involving 80 cats, with 251 swab samples collected from various body sites.
  • Bacteriological procedures and PCR targeting specific genes (nuc, pse, mecA) for bacterial identification and MRSA/MRSP detection.
  • Statistical analysis, including multivariable logistic regression, to identify risk factors.

Main Results:

  • Staphylococcus aureus was carried by 30% of cats and Staphylococcus pseudintermedius by 6.25%.
  • High antimicrobial resistance was observed, particularly to penicillin and ampicillin for S. aureus, and ampicillin, erythromycin, and ciprofloxacin for S. pseudintermedius.
  • Multidrug resistance (MDR) was prevalent in 91% of S. aureus and 40% of S. pseudintermedius isolates. Methicillin-resistant Staphylococcus aureus (MRSA) was detected in 11.43% of S. aureus isolates.

Conclusions:

  • The study highlights a significant prevalence of Staphylococcus aureus and Staphylococcus pseudintermedius carriage in cats, often associated with multidrug resistance (MDR) and MRSA.
  • Previous antibiotic use emerged as a risk factor for S. aureus colonization, while otitis externa and steroid use were linked to S. pseudintermedius carriage.
  • The findings underscore the importance of monitoring antimicrobial resistance in companion animals to guide clinical management and prevent the spread of resistant strains.
Keywords:
MDRMRSAS. aureusS. pseudintermediuscatsrisk factors

More Related Videos

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

24.6K
Genotyping of Staphylococcus aureus by Ribosomal Spacer PCR RS-PCR08:51

Genotyping of Staphylococcus aureus by Ribosomal Spacer PCR RS-PCR

Published on: November 4, 2016

9.7K

Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
143
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
219
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
90