Evaluating the association of ischemic ECG changes and CBC parameters in normal population
Mahdiyeh Yaghooti-Khorasani1,2, Naiemeh Varasteh2, Hossein Hatamzadeh3
1Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Insights
This study explored the link between complete blood count (CBC) and electrocardiogram (ECG) changes in a large normal population. Minor ischemic ECG changes were associated with red blood cell count, hemoglobin, and mean corpuscular volume.
Area of Science:
- Cardiology
- Hematology
- Public Health
Background:
- Investigating the relationship between complete blood count (CBC) parameters and ischemic electrocardiogram (ECG) changes in a large, healthy population.
- This study is the first to explore this association in such a cohort.
Purpose of the Study:
- To determine the association between CBC parameters and ischemic ECG changes.
- To identify potential hematological markers for ischemic ECG changes in a normal population.
Main Methods:
- A cross-sectional study of 9,106 participants from the MASHAD cohort.
- Ischemic ECG changes were classified as major or minor based on Minnesota codes.
- Logistic regression analysis was used to assess the association between CBC parameters and ECG changes, controlling for confounders.
Main Results:
- Major ischemic ECG changes showed no association with CBC parameters.
- Minor ischemic changes were associated with increased red blood cell count (OR=1.96) and mean corpuscular volume (OR=1.05).
- Higher hemoglobin levels were associated with decreased odds of minor ischemic changes (OR=0.81).
Conclusions:
- Major ischemic ECG changes in a normal population are not linked to CBC parameters.
- Minor ischemic ECG changes show associations with specific CBC parameters, including red blood cell count, hemoglobin, and MCV.
- Further research may elucidate the clinical implications of these findings.
Background:
Finding the relation between complete blood count (CBC) parameters and ischemic electrocardiogram (ECG) changes among a large normal population, for the first time.
Methods:
Participants of the first phase of the MASHAD cohort study were enrolled in this cross-sectional study. Twelve-lead ECGs were taken from participants. According to the Minnesota codes, we divided the ischemic ECG changes into major and minor. Major ischemic changes included major Q-wave changes, minor Q-wave plus ST-T changes, and major isolated ST-T changes. Minor changes included minor isolated Q/QS waves, minor ST/T changes, and ST-segment elevation. The mean of the CBC parameters was compared between individuals with and without ischemic changes. The backward stepwise logistic regression model was implemented to estimate the odds ratios of ECG changes and eliminate confounders. Data were analyzed using SPSS version 20, with significance set at p < 0.05.
Results:
Among 9,106 participants, 510 individuals (5.6%) had minor and major ischemic changes, with a preference for males. Major ischemic changes were not associated with CBC parameters. However, the odds of having minor ischemic changes increased 1.96-fold with increasing red blood cell (RBC) count (OR = 1.96 [1.31-2.94], p = 0.001); though, they decreased by 0.18 units with increasing hemoglobin (OR = 0.81 [0.73-0.92], p = 0.001). Additionally, high mean corpuscular volume (MCV) increased the odds of minor ischemic changes (OR = 1.05 [1.01-1.08], p = 0.004).
Conclusion:
Among Mashhad's normal population, major ischemic changes were not associated with CBC parameters. Also, minor and major ischemic changes were positively associated with WBC count.
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