Related Experiment Video
Updated: Sep 9, 2025
Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
Association between creatinine clearance and mortality in Chinese patients with osteoporotic fractures: a
Ming Su1,2, Peng Zhou1,2, Min-Zhe Xu1,2
1Department of Orthopedics, Affiliated Kunshan Hospital of Jiangsu University, Suzhou, Jiangsu, China.
Background:
Creatinine clearance (CCR) is a vital biomarker for evaluating renal function, indicating the efficiency of the kidneys in filtering blood waste. However, the link between CCR and mortality in hospitalized patients with osteoporotic fractures (OPFs) remains unclear. The increasing prevalence of OPFs in elderly populations, coupled with known complications of renal dysfunction, underscores the critical importance of understanding this relationship. This study aimed to investigate the association between CCR levels and mortality in a cohort of hospitalized patients with OPFs, with the goal of establishing evidence-based guidelines for risk stratification and management strategies.
Methods:
A retrospective cohort study analyzed data from 3,177 patients hospitalized with OPFs between 6 December 2018 and 31 December 2023. A multivariate Cox regression analysis was used to evaluate the relationship between CCR and mortality while adjusting for potential confounding variables, including laboratory parameters, clinical characteristics, and lifestyle factors. Subgroup analyses, smoothed curve fitting with threshold analyses, Kaplan-Meier curves, and sensitivity analyses were performed.
Results:
A linear correlation between CCR and mortality was observed, with each 1-point increment in CCR correlating with a 2% reduction in mortality risk (hazard ratio (HR) = 0.98; 95% confidence interval (CI): 0.97, 0.98; p < 0.01). Patients were categorized into three groups based on CCR: Group 1 (CCR ≤ 80 mL/min), Group 2 (80 < CCR ≤ 120 mL/min), and Group 3 (CCR > 120 mL/min). Group 2 exhibited a 51% lower hazard of mortality than Group 1 (HR = 0.49, 95% CI: 0.34, 0.71; p < 0.01), while Group 3 showed an 87% reduction in mortality risk (HR = 0.13, 95% CI: 0.05, 0.36; p < 0.01). Subgroup analyses confirmed the robustness of these findings even after adjusting for other covariates. Linear association was detected using smoothed curve fitting and threshold analysis. The Kaplan-Meier survival curves revealed a negative relationship between CCR levels and the cumulative mortality hazard. Sensitivity analyses demonstrated a stable direct association between CCR and the cumulative mortality hazard.
Conclusion:
This study demonstrated a significant association between CCR and mortality among hospitalized patients with OPFs, validating CCR as a valuable prognostic marker for assessing mortality risk.
More Related Videos
07:12Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
Published on: September 28, 2017
11:30A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
Related Concept Videos
01:17Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
01:23Renal Clearance
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
01:08Renal Drug Clearance: Comparison Between Renal Excretion Methods
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
01:06Renal Drug Clearance: Overview
Renal clearance can be calculated using different methods. One approach is to divide the urinary drug excretion rate by the plasma drug concentration. This method directly measures renal clearance, indicating the kidneys' efficiency in...
01:11Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
01:07Determination of Renal Drug Clearance: Graphical and Midpoint Methods
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...